AIP Advances
(Mar 2012)
Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
D. Doria,
K. F. Kakolee,
S. Kar,
S. K. Litt,
F. Fiorini,
H. Ahmed,
S. Green,
J. C. G. Jeynes,
J. Kavanagh,
D. Kirby,
K. J. Kirkby,
C. L. Lewis,
M. J. Merchant,
G. Nersisyan,
R. Prasad,
K. M. Prise,
G. Schettino,
M. Zepf,
M. Borghesi
Affiliations
D. Doria
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
K. F. Kakolee
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
S. Kar
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
S. K. Litt
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
F. Fiorini
School of Physics and Astronomy, University of Birmingham, B15 2TT, UK
H. Ahmed
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
S. Green
Hall Edwards Radiotherapy Research Group, Dept. of Medical Physics, University Hospital Birmingham, B15 2TH, UK
J. C. G. Jeynes
Ion Beam Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK
J. Kavanagh
Centre for Cancer Research and Cell Biology, Queen's University Belfast, BT9 7BL, UK
D. Kirby
School of Physics and Astronomy, University of Birmingham, B15 2TT, UK
K. J. Kirkby
Ion Beam Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK
C. L. Lewis
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
M. J. Merchant
Ion Beam Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK
G. Nersisyan
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
R. Prasad
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
K. M. Prise
Centre for Cancer Research and Cell Biology, Queen's University Belfast, BT9 7BL, UK
G. Schettino
Centre for Cancer Research and Cell Biology, Queen's University Belfast, BT9 7BL, UK
M. Zepf
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
M. Borghesi
Centre for Plasma Physics, Queen's University Belfast, BT7 1NN, UK
DOI
https://doi.org/10.1063/1.3699063
Journal volume & issue
Vol. 2,
no. 1
Abstract
Read online
The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.
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