Revista Cubana de Hematología, Inmunología y Hemoterapia (Aug 2002)
Reporte cubano del comportamiento de las inmunoglobulinas M, G y A en el curso de la infección por VIH y su relación con el conteo absoluto de linfocitos T CD4+ Cuban report on the behaviour of immunoglobulins M, G and A in the course of HIV infection and their relation with absolute CD4+ T lymphocyte count
Abstract
Con el objetivo de evaluar el comportamiento de las inmunoglobulinas (lgs) en pacientes VIH+ y su utilidad como marcadores evolutivos de la progresión de dicha infección, se cuantificaron las lgM, lgG e IgA en sueros de pacientes seropositivos y la subpoblación linfoide T CD4+. La población estudiada fue dividida en 3 grupos de 50 individuos, acorde con el conteo absoluto de linfocitos T CD4+: grupo 1 (³ 500 cel/µL), grupo 2 (200 a 499 cel/µL) y grupo 3 (To evaluate the behaviour of immunoglobulins (Igs) in HIV-positive patients and their usefulness as markers of the progression of the infection, IgM, IgG and IgA were quantified in sera from seropositive patients and the CD4+ T lymphoid subpopulation. The studied population was divided into 3 groups of 50 individuals according to the absolute CD4+ T lymphocyte count: group 1 (³ 500 cel/µL), group 2(200 a 499 cel/µL) and group 3 (<200 cel/µL). It was observed in the study that the levels of immunoglobulins increased as the number of CD4+ T lymphocytes reduced. The mean of IgM values was within the range of normal values for the 3 groups of patients; the mean of IgG values was over the normal range in the 3 study groups whereas that of the IgA values was over the normal ones only in group 3, which is a useful indicator of the infection staging. Also, a direct relation was observed in the increase of immunoglobulins but there was a reverse relation between Igs and the absolute CD4+T lymphocyte count
