Secondary Metabolites from Marine-Derived <i>Bacillus</i>: A Comprehensive Review of Origins, Structures, and Bioactivities
Shaoyujia Xiao,
Nan Chen,
Zixue Chai,
Mengdie Zhou,
Chenghaotian Xiao,
Shiqin Zhao,
Xiliang Yang
Affiliations
Shaoyujia Xiao
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
Nan Chen
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
Zixue Chai
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
Mengdie Zhou
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
Chenghaotian Xiao
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
Shiqin Zhao
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
Xiliang Yang
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Pharmacy, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
The marine is a highly complex ecosystem including various microorganisms. Bacillus species is a predominant microbialflora widely distributed in marine ecosystems. This review aims to provide a systematic summary of the newly reported metabolites produced by marine-derived Bacillus species over recent years covering the literature from 2014 to 2021. It describes the structural diversity and biological activities of the reported compounds. Herein, a total of 87 newly reported metabolites are included in this article, among which 49 compounds originated from marine sediments, indicating that marine sediments are majority sources of productive strains of Bacillus species Therefore, marine-derived Bacillus species are a potentially promising source for the discovery of new metabolites.
