An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint

Abstract

In response to chromatin bridges, the chromosomal passenger complex (CPC) delays completion of cytokinesis (abscission) to prevent chromosome breakage. Here, we discuss recent findings from our lab showing that an ATM-CHK2-INCENP pathway imposes the abscission checkpoint in human cells by regulating CPC midbody-localization.

Keywords

• chromatin bridges
• abscission checkpoint
• midbody
• cytokinesis
• atm
• chk2
• mrn
• incenp
• cpc