Nature Communications (Mar 2016)
A phosphotyrosine switch regulates organic cation transporters
- Jason A. Sprowl,
- Su Sien Ong,
- Alice A. Gibson,
- Shuiying Hu,
- Guoqing Du,
- Wenwei Lin,
- Lie Li,
- Shashank Bharill,
- Rachel A. Ness,
- Adrian Stecula,
- Steven M. Offer,
- Robert B. Diasio,
- Anne T. Nies,
- Matthias Schwab,
- Guido Cavaletti,
- Eberhard Schlatter,
- Giuliano Ciarimboli,
- Jan H. M. Schellens,
- Ehud Y. Isacoff,
- Andrej Sali,
- Taosheng Chen,
- Sharyn D. Baker,
- Alex Sparreboom,
- Navjotsingh Pabla
Affiliations
- Jason A. Sprowl
- Department of Pharmaceutical, Social and Administrative Sciences, School of Pharmacy, D’Youville College
- Su Sien Ong
- Department of Chemical Biology & Therapeutics, St Jude Children's Research Hospital
- Alice A. Gibson
- Division of Pharmaceutics, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University
- Shuiying Hu
- Division of Pharmaceutics, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University
- Guoqing Du
- Department of Oncology, St. Jude Children's Research Hospital
- Wenwei Lin
- Department of Chemical Biology & Therapeutics, St Jude Children's Research Hospital
- Lie Li
- Department of Pharmaceutical Sciences, St Jude Children's Research Hospital
- Shashank Bharill
- Department of Molecular and Cell Biology, University of California
- Rachel A. Ness
- Department of Pharmaceutical Sciences, St Jude Children's Research Hospital
- Adrian Stecula
- Department of Bioengineering and Therapeutic Sciences, University of California
- Steven M. Offer
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center
- Robert B. Diasio
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center
- Anne T. Nies
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376
- Matthias Schwab
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376
- Guido Cavaletti
- Department of Surgery and Translational Medicine, University of Milano-Bicocca
- Eberhard Schlatter
- Medical Clinic D, Experimental Nephrology and Interdisciplinary Center for Clinical Research (IZKF), Münster Medical Faculty
- Giuliano Ciarimboli
- Medical Clinic D, Experimental Nephrology and Interdisciplinary Center for Clinical Research (IZKF), Münster Medical Faculty
- Jan H. M. Schellens
- Division of Molecular Pathology, The Netherlands Cancer Institute
- Ehud Y. Isacoff
- Department of Molecular and Cell Biology, University of California
- Andrej Sali
- Department of Bioengineering and Therapeutic Sciences, University of California
- Taosheng Chen
- Department of Chemical Biology & Therapeutics, St Jude Children's Research Hospital
- Sharyn D. Baker
- Division of Pharmaceutics, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University
- Alex Sparreboom
- Division of Pharmaceutics, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University
- Navjotsingh Pabla
- Division of Pharmaceutics, College of Pharmacy & Comprehensive Cancer Center, The Ohio State University
- DOI
- https://doi.org/10.1038/ncomms10880
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug transporter function through post-translational mechanisms.
