Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites

• Jitka Dadová,
• Kuan-Jung Wu,
• Patrick G. Isenegger,
• James C. Errey,
• Gonçalo J. L. Bernardes,
• Justin M. Chalker,
• Lluís Raich,
• Carme Rovira,
• Benjamin G. Davis

Affiliations

Jitka Dadová

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.

Kuan-Jung Wu

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.

Patrick G. Isenegger

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.

James C. Errey

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.

Gonçalo J. L. Bernardes

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.

Justin M. Chalker

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.

Lluís Raich

Departament de Quı́mica Inorgànica i Orgànica (secció de Quı́mica Orgànica) & Institut de Quı́mica Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Barcelona, Spain

Carme Rovira

Departament de Quı́mica Inorgànica i Orgànica (secció de Quı́mica Orgànica) & Institut de Quı́mica Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Barcelona, Spain

Benjamin G. Davis

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, U.K.