Nature Communications (Jun 2017)

Structural insights into the function of ZRANB3 in replication stress response

  • Marek Sebesta,
  • Christopher D. O. Cooper,
  • Antonio Ariza,
  • Christopher J. Carnie,
  • Dragana Ahel

DOI
https://doi.org/10.1038/ncomms15847
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA.