Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

Mostafa M. Ghorab; Mansour S. Alsaid; Mohammed S. Al-Dosari; Marwa G. El-Gazzar; Mohammad K. Parvez

doi:10.3390/molecules21020189

Molecules (Feb 2016)

Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

Mostafa M. Ghorab,
Mansour S. Alsaid,
Mohammed S. Al-Dosari,
Marwa G. El-Gazzar,
Mohammad K. Parvez

Affiliations

Mostafa M. Ghorab: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Mansour S. Alsaid: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Mohammed S. Al-Dosari: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Marwa G. El-Gazzar: Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo 11371, Egypt
Mohammad K. Parvez: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

DOI: https://doi.org/10.3390/molecules21020189
Journal volume & issue: Vol. 21, no. 2
p. 189

Abstract

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By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provides an encouraging framework that could lead to the development of potent new anticancer agents.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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