Nature Communications (Jan 2018)

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

  • Philipp Neumann,
  • Nicolas Jaé,
  • Andrea Knau,
  • Simone F. Glaser,
  • Youssef Fouani,
  • Oliver Rossbach,
  • Marcus Krüger,
  • David John,
  • Albrecht Bindereif,
  • Phillip Grote,
  • Reinier A. Boon,
  • Stefanie Dimmeler

DOI
https://doi.org/10.1038/s41467-017-02431-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis.