Molecules (Sep 2024)

Polyphosphoric Acid-Promoted Efficient Synthesis of Cinnamides via Aldol Condensation of Amide

  • Enhua Wang,
  • Lishou Yang,
  • Lanfeng He,
  • Qian Yang,
  • Xue Wang,
  • Yunlu Liu,
  • Manxiang Li,
  • Yang Lei,
  • Xiaosheng Yang

DOI
https://doi.org/10.3390/molecules29194632
Journal volume & issue
Vol. 29, no. 19
p. 4632

Abstract

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Cinnamides are common core structures that exist in a great number of pharmaceuticals and natural products. The development of efficient methods for preparing cinnamides is in great need. We report herein an efficient polyphosphoric acid (PPA)-promoted direct aldol condensation of an amide for the convenient and straightforward preparation of cinnamides. A variety of cinnamides were obtained in moderate-to-excellent yields (65–89%). This strategy features the use of equivalent amides and a short reaction time.

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