Nature Communications (Apr 2023)
Conformational cycle of human polyamine transporter ATP13A2
- Jianqiang Mu,
- Chenyang Xue,
- Lei Fu,
- Zongjun Yu,
- Minhan Nie,
- Mengqi Wu,
- Xinmeng Chen,
- Kun Liu,
- Ruiqian Bu,
- Ying Huang,
- Baisheng Yang,
- Jianming Han,
- Qianru Jiang,
- Kevin C. Chan,
- Ruhong Zhou,
- Huilin Li,
- Ancheng Huang,
- Yong Wang,
- Zhongmin Liu
Affiliations
- Jianqiang Mu
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Chenyang Xue
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Lei Fu
- Shanghai Institute for Advanced Study, Institute of Quantitative Biology, College of Life Sciences, Zhejiang University
- Zongjun Yu
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Minhan Nie
- School of Pharmaceutical Sciences, Sun Yat-sen University, No.132 Wai Huan Dong Lu, Guangzhou Higher Education Mega Center
- Mengqi Wu
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Xinmeng Chen
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Kun Liu
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Ruiqian Bu
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Ying Huang
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Baisheng Yang
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Jianming Han
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Qianru Jiang
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Kevin C. Chan
- Shanghai Institute for Advanced Study, Institute of Quantitative Biology, College of Life Sciences, Zhejiang University
- Ruhong Zhou
- Shanghai Institute for Advanced Study, Institute of Quantitative Biology, College of Life Sciences, Zhejiang University
- Huilin Li
- School of Pharmaceutical Sciences, Sun Yat-sen University, No.132 Wai Huan Dong Lu, Guangzhou Higher Education Mega Center
- Ancheng Huang
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- Yong Wang
- Shanghai Institute for Advanced Study, Institute of Quantitative Biology, College of Life Sciences, Zhejiang University
- Zhongmin Liu
- Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-023-37741-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
ATP13A2 is a lysosomal polyamine transporter, mutated in several diseases including juvenile-onset Parkinson’s disease. Here, the authors report structures of human ATP13A2 in six distinct intermediate states, illustrating most of its conformational cycle.
