Nature Communications (Dec 2022)

Exon junction complex shapes the m6A epitranscriptome

  • Xin Yang,
  • Robinson Triboulet,
  • Qi Liu,
  • Erdem Sendinc,
  • Richard I. Gregory

DOI
https://doi.org/10.1038/s41467-022-35643-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Here the authors show the exon junction complex (EJC) component, EIF4A3, locally restricts METTL3- mediated mRNA methylation at exon junctions to explain the observed widespread enrichment of m6A modification in 3’ untranslated regions.