Case report: Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding

Margareta Fistrek Prlic; Mislav Jelakovic; Marko Brinar; Marko Brinar; Dora Grgic; Ivan Romic; Zlatko Marusic; Ema Ivandic; Bojan Jelakovic; Bojan Jelakovic; Ivana Vukovic Brinar; Ivana Vukovic Brinar; Zeljko Krznaric; Zeljko Krznaric

doi:10.3389/fmed.2023.1097469

Frontiers in Medicine (Apr 2023)

Case report: Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding

Margareta Fistrek Prlic,
Mislav Jelakovic,
Marko Brinar,
Marko Brinar,
Dora Grgic,
Ivan Romic,
Zlatko Marusic,
Ema Ivandic,
Bojan Jelakovic,
Bojan Jelakovic,
Ivana Vukovic Brinar,
Ivana Vukovic Brinar,
Zeljko Krznaric,
Zeljko Krznaric

Affiliations

Margareta Fistrek Prlic: Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Mislav Jelakovic: Department of Gastroenterology, University Hospital Center Zagreb, Zagreb, Croatia
Marko Brinar: Department of Gastroenterology, University Hospital Center Zagreb, Zagreb, Croatia
Marko Brinar: School of Medicine, University of Zagreb, Zagreb, Croatia
Dora Grgic: Department of Gastroenterology, University Hospital Center Zagreb, Zagreb, Croatia
Ivan Romic: Department of Abdominal Surgery, University Hospital Center Zagreb, Zagreb, Croatia
Zlatko Marusic: Department of Pathology, University Hospital Center Zagreb, Zagreb, Croatia
Ema Ivandic: Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Bojan Jelakovic: Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Bojan Jelakovic: School of Medicine, University of Zagreb, Zagreb, Croatia
Ivana Vukovic Brinar: Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Ivana Vukovic Brinar: School of Medicine, University of Zagreb, Zagreb, Croatia
Zeljko Krznaric: Department of Gastroenterology, University Hospital Center Zagreb, Zagreb, Croatia
Zeljko Krznaric: School of Medicine, University of Zagreb, Zagreb, Croatia

DOI: https://doi.org/10.3389/fmed.2023.1097469
Journal volume & issue: Vol. 10

Abstract

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Chronic kidney disease (CKD) is a very common chronic non-communicable disease. Phosphate and calcium metabolism disorders are one of the most common features of CKD. Sevelamer carbonate is the most widely used non-calcium phosphate binder. Gastrointestinal (GI) injury associated with sevelamer use is a documented adverse effect but is underrecognized as a cause of gastrointestinal symptoms in patients with CKD. We report a case of a 74-year-old woman taking low-dose sevelamer with serious gastrointestinal adverse effects causing colon rupture and severe gastrointestinal bleeding.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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