饱和脂肪酸的抗癌作用及其机制研究进展Advance in potential anti-cancer effect and mechanism of saturated fatty acids

Abstract

饮食中的饱和脂肪酸通常与人体健康的负面影响相关，然而有关各种饱和脂肪酸的生理效应、生物功能等研究结果存在一定的争议。综述了饱和脂肪酸的可能抗癌作用及作用机制，以期为癌症的辅助治疗提供一定的参考。目前对短链饱和脂肪酸、中链饱和脂肪酸、奇数链饱和脂肪酸、支链饱和脂肪酸抗癌作用的报道较多，饱和脂肪酸主要通过阻滞细胞周期、诱导细胞凋亡、抑制细胞迁移和调控细胞生长相关的信号通路，或通过影响相关基因的表达和转录因子的磷酸化水平来发挥抗癌作用 Dietary saturated fatty acids (SFAs) is usually associated with negative consequences for human health. However, there are some contradictory experimental results on the physiological effects and biological functions of various SFAs. The anti-cancer effects and mechanisms of SFAs were mainly summarized and discussed, so as to provide the way for adjuvant therapy of cancer. At present, there are many reports on the anti-cancer effects of short-chain SFAs, medium-chain SFAs, odd-chain SFAs and branched-chain SFAs, SFAs exert anti-cancer effects mainly by blocking the cell cycle, inducing apoptosis, inhibiting cell migration and regulating cell growth-related signalling pathways, and affecting the expression of related genes and the phosphorylation levels of transcription factors.

Keywords

• 饱和脂肪酸；抗癌作用；机制
• saturated fatty acid; anti-cancer effect; mechanism