Physiological and histological effects of broccoli on lead acetate Induced hepatotoxicity in young Male albino rats

Iraqi Journal of Veterinary Sciences. 2019;33(1):21-26 DOI 10.33899/ijvs.2019.125528.1050

 

Journal Homepage

Journal Title: Iraqi Journal of Veterinary Sciences

ISSN: 1607-3894 (Print); 2071-1255 (Online)

Publisher: University of Mosul, College of Veterinary Medicine

LCC Subject Category: Agriculture: Animal culture: Veterinary medicine

Country of publisher: Iraq

Language of fulltext: Arabic, English

Full-text formats available: PDF

 

AUTHORS

Sulaf Mohammed (Biology department, College of Science, University of Sulaimani)
Majida Noori Ibrahim (Biology department, College of Science, University of Kirkuk)
Mahmood Ahmed (Biology department, College of Science, University of Sulaimani)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 25 weeks

 

Abstract | Full Text

The aim of this study was to investigate the ameliorative effect of Broccoli against lead acetate (PbA) hepatotoxicity by some physiological and histological indicators. The results showed that intraperitoneal (I.P.) injection by 12 mg/kg body weight of lead acetate once a week for 8 weeks led to an increase in the activity of Glutamate pyruvate transaminase (GPT), Glutamate oxaloacetate transaminase (GOT), Alkaline phosphatase (ALP), Acid phosphatase (ACP), Total serum protein (TP) and Total serum bilirubin (TSB). Liver's histological sections of lead acetate injected rats showed infiltration of inflammatory cells with sinusoid dilation, necrosis, and apoptosis of Kupffer cells. Broccoli has an ameliorative effect, that the physiological parameters and histological examination have been showed an improvement. In conclusion, lead acetate produces hepatic disorder and the potential use of Broccoli as a source of natural antioxidants or nutraceuticals protects against lead acetate hepatic toxicity.