Nature Communications (Jan 2022)
Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry
- Mathieu Claireaux,
- Rémy Robinot,
- Jérôme Kervevan,
- Mandar Patgaonkar,
- Isabelle Staropoli,
- Anne Brelot,
- Alexandre Nouël,
- Stacy Gellenoncourt,
- Xian Tang,
- Mélanie Héry,
- Stevenn Volant,
- Emeline Perthame,
- Véronique Avettand-Fenoël,
- Julian Buchrieser,
- Thomas Cokelaer,
- Christiane Bouchier,
- Laurence Ma,
- Faroudy Boufassa,
- Samia Hendou,
- Valentina Libri,
- Milena Hasan,
- David Zucman,
- Pierre de Truchis,
- Olivier Schwartz,
- Olivier Lambotte,
- Lisa A. Chakrabarti
Affiliations
- Mathieu Claireaux
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Rémy Robinot
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Jérôme Kervevan
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Mandar Patgaonkar
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Isabelle Staropoli
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Anne Brelot
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Alexandre Nouël
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Stacy Gellenoncourt
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Xian Tang
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Mélanie Héry
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Stevenn Volant
- Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur, Université de Paris
- Emeline Perthame
- Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur, Université de Paris
- Véronique Avettand-Fenoël
- AP-HP Hôpital Necker-Enfants Malades, Laboratoire de Microbiologie clinique
- Julian Buchrieser
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Thomas Cokelaer
- Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur, Université de Paris
- Christiane Bouchier
- Biomics Platform, C2RT, Institut Pasteur, Université de Paris
- Laurence Ma
- Biomics Platform, C2RT, Institut Pasteur, Université de Paris
- Faroudy Boufassa
- INSERM U1018, Center for Research in Epidemiology and Population Health (CESP)
- Samia Hendou
- INSERM U1018, Center for Research in Epidemiology and Population Health (CESP)
- Valentina Libri
- Cytometry and Biomarkers (CB UTechS), Translational Research Center, Institut Pasteur, Université de Paris
- Milena Hasan
- Cytometry and Biomarkers (CB UTechS), Translational Research Center, Institut Pasteur, Université de Paris
- David Zucman
- HIV Unit, Foch Hospital
- Pierre de Truchis
- AP-HP, Infectious and Tropical Diseases Department, Raymond Poincaré Hospital
- Olivier Schwartz
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- Olivier Lambotte
- INSERM U1184, Université Paris Sud, CEA, Center for Immunology of Viral Infections and Autoimmune Diseases
- Lisa A. Chakrabarti
- Virus and Immunity Unit, Institut Pasteur, Université de Paris
- DOI
- https://doi.org/10.1038/s41467-022-28130-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Here, Claireaux et al. show that people who naturally control HIV infection express lower levels of the viral co-receptor CCR5 in specific CD4+ T cells, and that this results from mutations or receptor internalization by CD4+ T cell-produced chemokines.
