Genetic evidence for assortative mating on alcohol consumption in the UK Biobank

Laurence J. Howe; Daniel J. Lawson; Neil M. Davies; Beate St. Pourcain; Sarah J. Lewis; George Davey Smith; Gibran Hemani

doi:10.1038/s41467-019-12424-x

Nature Communications (Nov 2019)

Genetic evidence for assortative mating on alcohol consumption in the UK Biobank

Laurence J. Howe,
Daniel J. Lawson,
Neil M. Davies,
Beate St. Pourcain,
Sarah J. Lewis,
George Davey Smith,
Gibran Hemani

Affiliations

Laurence J. Howe: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
Daniel J. Lawson: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
Neil M. Davies: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
Beate St. Pourcain: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
Sarah J. Lewis: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
George Davey Smith: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol
Gibran Hemani: Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol

DOI: https://doi.org/10.1038/s41467-019-12424-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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From observational studies, alcohol consumption behaviours are known to be correlated in spouses. Here, Howe et al. use partners’ genotypic information in a Mendelian randomization framework and show that a SNP in the ADH1B gene associates with partner’s alcohol consumption, suggesting that alcohol consumption affects mate choice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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