Nature Communications (Oct 2016)
A distinct holoenzyme organization for two-subunit pyruvate carboxylase
Abstract
Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected α2β4stoichiometry.