Nature Communications (May 2020)
YAP1/TAZ drives ependymoma-like tumour formation in mice
- Noreen Eder,
- Federico Roncaroli,
- Marie-Charlotte Domart,
- Stuart Horswell,
- Felipe Andreiuolo,
- Helen R. Flynn,
- Andre T. Lopes,
- Suzanne Claxton,
- John-Paul Kilday,
- Lucy Collinson,
- Jun-Hao Mao,
- Torsten Pietsch,
- Barry Thompson,
- Ambrosius P. Snijders,
- Sila K. Ultanir
Affiliations
- Noreen Eder
- Kinases and Brain Development Laboratory, The Francis Crick Institute
- Federico Roncaroli
- Manchester Centre for Clinical Neuroscience, Salford Royal NHS Foundation Trust, Salford and Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biology, University of Manchester
- Marie-Charlotte Domart
- Electron Microscopy Platform, The Francis Crick Institute
- Stuart Horswell
- Bioinformatics and Biostatistics Platform, The Francis Crick Institute
- Felipe Andreiuolo
- Institute of Neuropathology, DGNN Brain Tumour Reference Center, University of Bonn
- Helen R. Flynn
- Protein Analysis and Proteomics Platform, The Francis Crick Institute
- Andre T. Lopes
- Kinases and Brain Development Laboratory, The Francis Crick Institute
- Suzanne Claxton
- Kinases and Brain Development Laboratory, The Francis Crick Institute
- John-Paul Kilday
- Centre for Paediatric, Teenage and Young Adult Cancer, Faculty of Biology, Medicine and Health, University of Manchester
- Lucy Collinson
- Electron Microscopy Platform, The Francis Crick Institute
- Jun-Hao Mao
- Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School
- Torsten Pietsch
- Institute of Neuropathology, DGNN Brain Tumour Reference Center, University of Bonn
- Barry Thompson
- Epithelial Biology Laboratory, The Francis Crick Institute
- Ambrosius P. Snijders
- Protein Analysis and Proteomics Platform, The Francis Crick Institute
- Sila K. Ultanir
- Kinases and Brain Development Laboratory, The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-020-16167-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
