Retrovirology (Oct 2006)

HIV infection of non-dividing cells: a divisive problem

  • Fassati Ariberto

DOI
https://doi.org/10.1186/1742-4690-3-74
Journal volume & issue
Vol. 3, no. 1
p. 74

Abstract

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Abstract Understanding how lentiviruses can infect terminally differentiated, non-dividing cells has proven a very complex and controversial problem. It is, however, a problem worth investigating, for it is central to HIV-1 transmission and AIDS pathogenesis. Here I shall attempt to summarise what is our current understanding for HIV-1 infection of non-dividing cells. In some cases I shall also attempt to make sense of controversies in the field and advance one or two modest proposals.