Nature Communications (Jan 2022)
GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models
Abstract
Immunologically cold tumours don’t respond to immune checkpoint blockade inhibition due to poor recruitment of anti-tumour T cells. Authors show here that melanoma-associated lymphatic endothelial cells express G Protein-Coupled Receptor 182 that scavenges CXCL9 and other chemokines necessary for T cell recruitment.