Nature Communications (May 2019)
Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
- Yu-Cheng Lee,
- Antonina V. Kurtova,
- Jing Xiao,
- Fotis Nikolos,
- Kazukuni Hayashi,
- Zoe Tramel,
- Antrix Jain,
- Fengju Chen,
- Mithil Chokshi,
- Ciaran Lee,
- Gang Bao,
- Xiang Zhang,
- Jianjun Shen,
- Qianxing Mo,
- Sung Yun Jung,
- David Rowley,
- Keith Syson Chan
Affiliations
- Yu-Cheng Lee
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Antonina V. Kurtova
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Jing Xiao
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Fotis Nikolos
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Kazukuni Hayashi
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Zoe Tramel
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Antrix Jain
- Department of Biochemistry and Molecular Biology, Mass Spectrometry Proteomics Core, Baylor College of Medicine
- Fengju Chen
- Dan L Duncan Cancer Center, Baylor College of Medicine
- Mithil Chokshi
- Department of Bioengineering, Rice University Houston
- Ciaran Lee
- Department of Bioengineering, Rice University Houston
- Gang Bao
- Department of Bioengineering, Rice University Houston
- Xiang Zhang
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Jianjun Shen
- University of Texas M.D. Anderson Cancer Center
- Qianxing Mo
- Department of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute
- Sung Yun Jung
- Department of Biochemistry and Molecular Biology, Mass Spectrometry Proteomics Core, Baylor College of Medicine
- David Rowley
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Keith Syson Chan
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-09878-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating these collagen III/CD167a-driven metastatic foci.
