SIRT1 accelerates the progression of activity-based anorexia

Timothy M. Robinette; Justin W. Nicholatos; Adam B. Francisco; Kayla E. Brooks; Rachel Y. Diao; Sandro Sorbi; Valdo Ricca; Benedetta Nacmias; Miguel A. Brieño-Enríquez; Sergiy Libert

doi:10.1038/s41467-020-16348-9

Nature Communications (Jun 2020)

SIRT1 accelerates the progression of activity-based anorexia

Timothy M. Robinette,
Justin W. Nicholatos,
Adam B. Francisco,
Kayla E. Brooks,
Rachel Y. Diao,
Sandro Sorbi,
Valdo Ricca,
Benedetta Nacmias,
Miguel A. Brieño-Enríquez,
Sergiy Libert

Affiliations

Timothy M. Robinette: Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
Justin W. Nicholatos: Department of Biomedical Sciences, Cornell University
Adam B. Francisco: Department of Biomedical Sciences, Cornell University
Kayla E. Brooks: Department of Biomedical Sciences, Cornell University
Rachel Y. Diao: Department of Biomedical Sciences, Cornell University
Sandro Sorbi: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence
Valdo Ricca: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence
Benedetta Nacmias: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence
Miguel A. Brieño-Enríquez: Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
Sergiy Libert: Department of Biomedical Sciences, Cornell University

DOI: https://doi.org/10.1038/s41467-020-16348-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Anorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity-based anorexia model, suggesting SIRT1 could be a potential therapeutic target.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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