Study of Cytotoxic and Antibacterial Activity of Ag‐ and Mg‐Dual‐Doped ZnO Nanoparticles
Dr. Aytan Azizi,
Dr. Mohammad Ghasemirad,
Dr. Bardia Mortezagholi,
Dr. Emad Movahed,
Dr. Seyed Sasan Aryanezhad,
Dr. Ali Makiya,
Dr. Hoda Ghodrati,
Dr. Kamyar Nasiri
Affiliations
Dr. Aytan Azizi
Department of Endodontics Dental School Qazvin university of medical sciences shahid bahounar boulevard, P.O. Box: 3419759811 Qazvin Iran
Dr. Mohammad Ghasemirad
Department of Periodontics Faculty of Dentistry Rafsanjan University of Medical Sciences Khalije Fars Blvd., Pasdaran street, P.O. Box: 1946853314 Rafsanjan Iran
Dr. Bardia Mortezagholi
Dental Research Center Faculty of Dentistry Islamic Azad University of Medical Sciences Shariati St, P.O. Box 19395-1495 Tehran Iran
Dr. Emad Movahed
Dental Research Center Faculty of Dentistry Islamic Azad University of Medical Sciences Shariati St, P.O. Box 19395-1495 Tehran Iran
Dr. Seyed Sasan Aryanezhad
Oral and Maxillofacial Radiology, Private Practice Daroost street, P.O. Box 1944614581 Tehran Iran
Dr. Ali Makiya
Student Research Committee, Faculty of Dentistry Mashhad University of Medical Science Mashhad Iran
Dr. Hoda Ghodrati
Department of Prosthodontics Shahid Beheshti University of Medical Sciences Daneshjoo Blvd, Velenjak, St., P.O. Box 1983969411 Tehran Iran
Dr. Kamyar Nasiri
Department of dentistry Islamic Azad University of Medical Sciences P.O. Box 19585-466 Tehran Iran
Abstract A non‐laborious process for the fabrication of silver and magnesium dual doped zinc oxide nanoparticles (Ag/Mg−ZnO NP) is described. The wurtzite ZnO nano‐structures and the dual doped NP were analyzed by PXRD. SEM data showed the hexagonal morphology of our product, while the gathered anti‐bacterial outcomes towards Streptococcus mutans bacteria through micro‐dilution technic affirmed the enhanced performance of doped NP compared to the native ones. Furthermore, we gauged the toxic impacts of synthesized pure and Ag/Mg−ZnO NP against a breast cancer (MDA‐MB‐231) cell line through an MTT trial, which highlighted the superiority of the doped when compared to the native nanoparticles. In light of these comparisons, the applicability of Ag/Mg−ZnO NP in dental and medical science is proposed.
