Translational Neuroscience (Oct 2023)

Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells

  • Bao Li,
  • Lan Xiao-Mei,
  • Zhang Guo-Qing,
  • Bao Xi,
  • Li Bo,
  • Ma Dan-Na,
  • Luo Hong-Yan,
  • Cao Shi-Lu,
  • Liu Shun-Yao,
  • Jing E,
  • Zhang Jian-Zhong,
  • Zheng Ya-Li

DOI
https://doi.org/10.1515/tnsci-2022-0318
Journal volume & issue
Vol. 14, no. 1
pp. 8001 – 12

Abstract

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Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells. However, the function of Cdk5 on the transformation of immortalized Cos-7 cells into neuronal-like cells is not clear.

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