Exploring the active ingredients and mechanism of qianglidingxuan tablets for vertigo based on network pharmacology and molecular docking

Abstract

Vertigo is a common disease, which is a kind of motor or positional illusion caused by the obstacle of spatial positioning. Qianglidingxuan Tablets (QLDX) tablets tablet has a significant effect in the treatment of vertigo, but its active components and mechanism is not clear. In this study, we explored the effective components and mechanism of QLDX tablets in treating vertigo using network pharmacology and molecular docking. Herein, we found 163 potential targets corresponding to 60 bio-active components of QLDX tablets, and 160 known vertigo-related targets. Among which, 41 targets were shared between potential targets of QLDX tablets and known vertigo related targets. The mainly active components included flavonoids, volatile oil, alkaloid, and polysaccharides. Potential targets mainly regulating of cell response to chemical stress, oxidative stress, reactive oxygen species, epithelial cell proliferation, lipopolysaccharide, apoptosis signal pathway and steroid hormones. Additionally, molecular docking verified that the active compounds suchilactone in Gastrodia rhizome, epicatechin and liriodendrin in Eucommia ulmoides bark, myricanone in Ligusticum chuaxion, acacetin-7-O-β-D-galactopyranoside in Wild chrysanthemum, and kaempferol in Eucommia ulmoides leaves with the top core genes ESR, AR, ERBB2, EGFR, MAPK1 and CASP8. This work systematically explored the anti-vertigo mechanism of QLDX tablets and provides a novel perspective for future pharmacological research.

Keywords

• Vertigo
• Qianglidingxuan tablets
• Network pharmacology
• Chinese medicine formula
• Targets discovery