Hippocampal volumetry: Normative data in the Indian population

Abstract

Background: Mesial temporal sclerosis (MTS) is the most common cause of temporal lobe epilepsy. Quantitative analysis of the hippocampus using volumetry is commonly being used in the diagnosis of MTS and is being used as a marker in prognostication of seizure control. Although normative data for hippocampal volume (HV) is available for the western population, no such data is available for the Indian population. Aim: The aim of the study was to establish normative data for HV for the Indian population, which can aid in the accurate diagnosis of MTS. Materials and Methods: Magnetic resonance imaging (MRI) scans of 200 healthy volunteers were acquired using a 3 Tesla (3T) MRI scanner. Manual segmentation and volumetry was done using Siemens Syngo software. The data was analyzed using two tailed t-test to detect associations between HV and age, gender, and education. The data so obtained was also correlated with the data available from the rest of the world. Results: A mean HV of 2.411 cm 3 (standard deviation -0.299) was found in the study, which was significantly smaller when compared to the data from the western population. The right hippocampus was larger than the left, with a mean volume of 2.424 cm 3 and 2.398 cm 3 , respectively. HV was detected to be significantly higher in males. No association was found between HV and age and education. Conclusion: The values obtained in this study may be adopted as a standard in the evaluation of patients with intractable epilepsy.

Keywords

• Manual hippocampal volumetry
• manual hippocampal segmentation
• mesial temporal sclerosis
• normative data