The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery
Nurdana Kanasheva,
Dmitry A. Fedorishin,
Maria V. Lyapunova,
Mikhail V. Bukterov,
Olga A. Kaidash,
Abdigali A. Bakibaev,
Rakhmetulla Yerkassov,
Togzhan Mashan,
Rimma Nesmeyanova,
Vladimir V. Ivanov,
Elena V. Udut,
Vera P. Tuguldurova,
Margarita V. Salina,
Victor S. Malkov,
Alexey S. Knyazev
Affiliations
Nurdana Kanasheva
Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan
Dmitry A. Fedorishin
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Maria V. Lyapunova
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Mikhail V. Bukterov
Central Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia
Olga A. Kaidash
Central Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia
Abdigali A. Bakibaev
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Rakhmetulla Yerkassov
Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan
Togzhan Mashan
Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan
Rimma Nesmeyanova
Department of Chemistry and Chemical Technologies, Faculty of Natural Sciences, Toraighyrov University, Pavlodar 140008, Kazakhstan
Vladimir V. Ivanov
Central Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia
Elena V. Udut
Central Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia
Vera P. Tuguldurova
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Margarita V. Salina
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Victor S. Malkov
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Alexey S. Knyazev
Faculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia
Due to traumatic injuries, including those from surgical procedures, adhesions occur in over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive measures can be implemented during abdominal organ surgeries. These measures involve creating a barrier around internal organs to forestall adhesion formation in the postoperative phase. Yet, the effectiveness of the artificial barrier relies on considerations of its biocompatibility and the avoidance of adverse effects on the body. This study explores the biocompatibility aspects, encompassing hemocompatibility, cytotoxicity, and antibacterial and antioxidant activities, as well as the adhesion of blood serum proteins and macrophages to the surface of new composite film materials. The materials, derived from the sodium salt of carboxymethylcellulose modified by glycoluril and allantoin, were investigated. The research reveals that film materials with a heterocyclic fragment exhibit biocompatibility comparable to commercially used samples in surgery. Notably, film samples developed with glycoluril outperform the effects of commercial samples in certain aspects.
