Pulmonary Circulation (Mar 2020)
Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
- Manuel J. Richter,
- Satenik Harutyunova,
- Tom Bollmann,
- Simon Classen,
- Jan Fuge,
- Henning Gall,
- Felix Gerhardt,
- Hossein A. Ghofrani,
- Hartmut Gunkel,
- Ekkehard Grünig,
- Michael Halank,
- Alexander Heine,
- Hans Klose,
- Tobias J. Lange,
- Claus Neurohr,
- Kai Nickolaus,
- Christian F. Opitz,
- Stephan Rosenkranz,
- Hans-Jürgen Seyfarth,
- Khodr Tello,
- Ralf Ewert,
- Karen M. Olsson
Affiliations
- Manuel J. Richter
- German Center for Lung Research (DZL), Giessen, Germany
- Satenik Harutyunova
- Center for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg, Heidelberg, Germany
- Tom Bollmann
- Department of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany
- Simon Classen
- Department of Vascular Surgery, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany
- Jan Fuge
- Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
- Henning Gall
- German Center for Lung Research (DZL), Giessen, Germany
- Felix Gerhardt
- Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany
- Hossein A. Ghofrani
- Department of Medicine, Imperial College London, London, UK
- Hartmut Gunkel
- pro-samed GmbH, Berlin, Germany
- Ekkehard Grünig
- Center for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg, Heidelberg, Germany
- Michael Halank
- Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
- Alexander Heine
- Department of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany
- Hans Klose
- Department of Pneumology, University of Hamburg, Hamburg, Germany
- Tobias J. Lange
- Department of Internal Medicine II, Division of Pneumology, University Medical Center Regensburg, Regensburg, Germany
- Claus Neurohr
- Department for Pneumology and Respiratory Medicine, Robert-Bosch-Hospital, Gerlingen, Germany
- Kai Nickolaus
- Department of Pneumology, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany
- Christian F. Opitz
- Department of Cardiology, DRK Kliniken Berlin, Berlin, Germany
- Stephan Rosenkranz
- Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany
- Hans-Jürgen Seyfarth
- Department of Pneumology, University of Leipzig, Leipzig, Germany
- Khodr Tello
- German Center for Lung Research (DZL), Giessen, Germany
- Ralf Ewert
- Department of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany
- Karen M. Olsson
- Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
- DOI
- https://doi.org/10.1177/2045894020910136
- Journal volume & issue
-
Vol. 10
Abstract
Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.
