Topology of brain functional connectivity networks in posttraumatic stress disorder
Teddy J. Akiki,
Christopher L. Averill,
Kristen M. Wrocklage,
J. Cobb Scott,
Lynnette A. Averill,
Brian Schweinsburg,
Aaron Alexander-Bloch,
Brenda Martini,
Steven M. Southwick,
John H. Krystal,
Chadi G. Abdallah
Affiliations
Teddy J. Akiki
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Christopher L. Averill
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Kristen M. Wrocklage
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States; Gaylord Specialty Healthcare, Department of Psychology, Wallingford, CT, United States
J. Cobb Scott
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; VISN4 Mental Illness Research, Education, and Clinical Center at the Philadelphia VA Medical Center, Philadelphia, PA, United States
Lynnette A. Averill
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Brian Schweinsburg
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Aaron Alexander-Bloch
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Brenda Martini
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Steven M. Southwick
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
John H. Krystal
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States
Chadi G. Abdallah
National Center for PTSD – Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States; Correspondence to: Clinical Neurosciences Division – VA National Center for PTSD; Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, 151E, West Haven, CT 06516, United States. Fax: +1 203 937 3481.
Here we present functional neuroimaging-based network data (focused on the default mode network) collected from a cohort of US Veterans with history of combat exposure, combined with clinical assessments for PTSD and other psychiatric comorbidities. The data has been processed and analyzed using several network construction methods (signed, thresholded, normalized to phase-randomized and rewired surrogates, functional and multimodal parcellation). An interpretation and discussion of the data can be found in the main NeuroImage article by Akiki et al. [51] Keywords: fMRI, PTSD, Functional connectivity, Graph theory, Veterans, Intrinsic connectivity networks, Default mode network
