Genome-guided discovery of cancer therapeutic targets

Prathyusha Konda; Simon Garinet; Eliezer M. Van Allen; Srinivas R. Viswanathan

Cell Reports (Aug 2023)

Genome-guided discovery of cancer therapeutic targets

Prathyusha Konda,
Simon Garinet,
Eliezer M. Van Allen,
Srinivas R. Viswanathan

Affiliations

Prathyusha Konda: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Simon Garinet: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Eliezer M. Van Allen: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA
Srinivas R. Viswanathan: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Corresponding author

Journal volume & issue: Vol. 42, no. 8
p. 112978

Abstract

Read online

Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets.

CP: Cancer

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

About the journal

Abstract

Keywords