Nature Communications (Aug 2020)

Human NMD ensues independently of stable ribosome stalling

  • Evangelos D. Karousis,
  • Lukas-Adrian Gurzeler,
  • Giuditta Annibaldis,
  • René Dreos,
  • Oliver Mühlemann

DOI
https://doi.org/10.1038/s41467-020-17974-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is not activated by stable ribosome stalling as previously suggested.