Human NMD ensues independently of stable ribosome stalling

Evangelos D. Karousis; Lukas-Adrian Gurzeler; Giuditta Annibaldis; René Dreos; Oliver Mühlemann

doi:10.1038/s41467-020-17974-z

Nature Communications (Aug 2020)

Human NMD ensues independently of stable ribosome stalling

Evangelos D. Karousis,
Lukas-Adrian Gurzeler,
Giuditta Annibaldis,
René Dreos,
Oliver Mühlemann

Affiliations

Evangelos D. Karousis: Department of Chemistry and Biochemistry, University of Bern
Lukas-Adrian Gurzeler: Department of Chemistry and Biochemistry, University of Bern
Giuditta Annibaldis: Department of Chemistry and Biochemistry, University of Bern
René Dreos: Center for Integrative Genomics, Université de Lausanne
Oliver Mühlemann: Department of Chemistry and Biochemistry, University of Bern

DOI: https://doi.org/10.1038/s41467-020-17974-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is not activated by stable ribosome stalling as previously suggested.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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