Effects of Home-Based Electrical Stimulation on Plasma Cytokines Profile, Redox Biomarkers, and Metalloproteinases in the Heart Failure with Reduced Ejection Fraction: A Randomized Trial

Marianne Lucena da Silva; Ivo Vieira de Sousa Neto; Alexandra C. G. B. de Lima; Fabrício Barin; Otávio de Toledo Nóbrega; Rita de Cássia Marqueti; Graziella F. B. Cipriano; João Luiz Quagliotti Durigan; Eduardo Antônio Ferreira; Martim Bottaro; Ross Arena; Larry P. Cahalin; José Alberto Neder; Gerson Cipriano Junior

doi:10.3390/jcdd9120463

Journal of Cardiovascular Development and Disease (Dec 2022)

Effects of Home-Based Electrical Stimulation on Plasma Cytokines Profile, Redox Biomarkers, and Metalloproteinases in the Heart Failure with Reduced Ejection Fraction: A Randomized Trial

Marianne Lucena da Silva,
Ivo Vieira de Sousa Neto,
Alexandra C. G. B. de Lima,
Fabrício Barin,
Otávio de Toledo Nóbrega,
Rita de Cássia Marqueti,
Graziella F. B. Cipriano,
João Luiz Quagliotti Durigan,
Eduardo Antônio Ferreira,
Martim Bottaro,
Ross Arena,
Larry P. Cahalin,
José Alberto Neder,
Gerson Cipriano Junior

Affiliations

Marianne Lucena da Silva: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Ivo Vieira de Sousa Neto: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Alexandra C. G. B. de Lima: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Fabrício Barin: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Otávio de Toledo Nóbrega: Department of Medicine, University of Brasilia (UnB), Campus Universitário Darcy Ribeiro, Asa Norte, Brasilia 70910-900, DF, Brazil
Rita de Cássia Marqueti: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Graziella F. B. Cipriano: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
João Luiz Quagliotti Durigan: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Eduardo Antônio Ferreira: Department of Pharmacy, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil
Martim Bottaro: Department of Physical Education, University of Brasilia (UnB), Campus Universitário Darcy Ribeiro, Asa Norte, Brasilia 70910-900, DF, Brazil
Ross Arena: Department of Physical Therapy, University of Illinois, 1919 W Taylor St., Chicago, IL 60612, USA
Larry P. Cahalin: Department of Physical Therapy, Leonard M. Miller School of Medicine, University of Miami, 5915 Ponce de Leon Blvd., 5th Floor, Coral Gables, FL 33101, USA
José Alberto Neder: Department of Medicine, School of Medicine at the Queen’s University, Queen’s University & Kingston General Hospital, Etherington Hall, Rooms 3032-3043, 94 Stuart Street, Kingston, ON K7L 3N6, Canada
Gerson Cipriano Junior: Rehabilitation Sciences and Health Sciences and Technologies Ph.D. Program, University of Brasilia (UnB), Campus Universitário, s/n, Centro Metropolitano, Brasilia 72220-275, DF, Brazil

DOI: https://doi.org/10.3390/jcdd9120463
Journal volume & issue: Vol. 9, no. 12
p. 463

Abstract

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Background: Low-frequency electrical stimulation (LFES) is an adjuvant method for heart failure (HF) patients with restrictions to start an exercise. However, the impact on molecular changes in circulating is unknown. We investigated the effects of 10 weeks of home-based LFES on plasma cytokines profile, redox biomarkers, metalloproteinases (MMPs) activity, and exercise performance in HF patients. Methods: Twenty-four HF patients (52.45 ± 9.15 years) with reduced ejection fraction (HFrEF) (EF p = 0.0001), while it decreased the active-MMP9 (0.135 to 0.093, p = 0.02). However, it did not elicit changes in cytokines, redox biomarkers, or exercise performance (p > 0.05). Conclusion: LFES protocol is a promising intervention to modulate MMPs activity in HFrEF patients, although with limited functional effects. These preliminary responses may help the muscle to adapt to future mechanical demands dynamically.

Published in Journal of Cardiovascular Development and Disease

ISSN: 2308-3425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: http://www.mdpi.com/journal/jcdd

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