Indian Journal of Pathology and Microbiology (Jan 2011)

Naturally occurring anti M complicating ABO grouping

  • Safoorah Khalid,
  • Roelyn Dantes,
  • Sunu Varghese,
  • Imadeddin Al Hakawati

DOI
https://doi.org/10.4103/0377-4929.77394
Journal volume & issue
Vol. 54, no. 1
pp. 170 – 172

Abstract

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Anti M is considered a naturally occurring antibody that is usually active at temperatures below 37°C and is thus of no clinical significance. This antibody, if present in an individual, can lead to a discrepancy between forward and reverse ABO grouping and thus creates diagnostic difficulties for blood bank staff. We report a case of a 58-year-old lady who had an unexpected reaction in reverse grouping due to anti M that posed a problem for us in the interpretation of results of her blood group. We also reviewed the literature to find out the significance of such discrepancy in blood grouping.

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