Chronic obstructive pulmonary disease and type 2 diabetes mellitus – diseases with cytokine imbalance
Abstract
Introduction. Cytokine imbalance is a topical issue of researches in the field of comorbid pathology, in particular, chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (DM2).The objective was to establish the characteristics of serum IL-6 levels in patients with a combination of COPD and DM2.Methods and materials. In the groups of patients with COPD (51 people), DM2 (42 people), COPD with DM2 (39 people), the control group (39 people), IL-6 was determined by enzyme immunoassay (standard test systems) on a StatFax 303Plus spectrophotometer. Computed tomography of the chest was performed on Optima 660 GE and Optima 540 tomographs using an image processing program on the AW SERVER 2.0. IBM SPSS Statistics software was used for statistical processing of the results.Results. A negative correlation was found between the level of IL-6 and the duration of COPD in patients with COPD in combination with DM2 (r=–0.373, p=0.033). In this group, there was a positive correlation between the level of IL-6 and the dose of dexamethasone (r=0.802, p=0.030). Among COPD patients, IL-6 levels were significantly lower in the subgroups of patients receiving glucocorticosteroid through a nebuliser (p=0.046), as well as patients receiving antibiotics (p=0.004). An algorithm for radiological methods of examination in patients with a combination of COPD and DM2 is proposed.Conclusion. The study of the features of the pathogenesis of a combination of COPD and DM2 is of practical interest for the individualization of management tactics in patients of this group.
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