Nature Communications (Nov 2018)
Active intermixing of indirect and direct neurons builds the striatal mosaic
- Andrea Tinterri,
- Fabien Menardy,
- Marco A. Diana,
- Ludmilla Lokmane,
- Maryama Keita,
- Fanny Coulpier,
- Sophie Lemoine,
- Caroline Mailhes,
- Benjamin Mathieu,
- Paloma Merchan-Sala,
- Kenneth Campbell,
- Ildiko Gyory,
- Rudolf Grosschedl,
- Daniela Popa,
- Sonia Garel
Affiliations
- Andrea Tinterri
- Brain Development and Plasticity Team, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Fabien Menardy
- Neurophysiology of Brain Circuits Team, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Marco A. Diana
- UPMC University Paris 06, UM119 Neuroscience Paris Seine (NPS), CNRS UMR8246, Inserm
- Ludmilla Lokmane
- Brain Development and Plasticity Team, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Maryama Keita
- Brain Development and Plasticity Team, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Fanny Coulpier
- Genomics Facility, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Sophie Lemoine
- Genomics Facility, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Caroline Mailhes
- Acute Transgenesis Facility, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Benjamin Mathieu
- Photon Microscopy Facility, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Paloma Merchan-Sala
- Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center
- Kenneth Campbell
- Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center
- Ildiko Gyory
- Department of Cellular and Molecular Immunology, Max Plank Institute of Immunobiology
- Rudolf Grosschedl
- Department of Cellular and Molecular Immunology, Max Plank Institute of Immunobiology
- Daniela Popa
- Neurophysiology of Brain Circuits Team, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- Sonia Garel
- Brain Development and Plasticity Team, Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris
- DOI
- https://doi.org/10.1038/s41467-018-07171-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Striatal projection neurons exist as two distinct classes and are anatomically mixed in the brain. Here, Tinterri and colleagues show the developmental mechanism of this cellular mosaicism that relies on an intrinsic transcription factor for cell type specification and intermixed cellular migration.
