Frontiers in Cardiovascular Medicine (Aug 2022)

Diabetic dyslipidemia impairs coronary collateral formation: An update

  • Ying Shen,
  • Xiao Qun Wang,
  • Yang Dai,
  • Yi Xuan Wang,
  • Rui Yan Zhang,
  • Rui Yan Zhang,
  • Lin Lu,
  • Lin Lu,
  • Feng Hua Ding,
  • Wei Feng Shen,
  • Wei Feng Shen

DOI
https://doi.org/10.3389/fcvm.2022.956086
Journal volume & issue
Vol. 9

Abstract

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Coronary collateralization is substantially impaired in patients with type 2 diabetes and occlusive coronary artery disease, which leads to aggravated myocardial ischemia and a more dismal prognosis. In a diabetic setting, altered serum lipid profiles and profound glycoxidative modification of lipoprotein particles induce endothelial dysfunction, blunt endothelial progenitor cell response, and severely hamper growth and maturation of collateral vessels. The impact of dyslipidemia and lipid-lowering treatments on coronary collateral formation has become a topic of heightened interest. In this review, we summarized the association of triglyceride-based integrative indexes, hypercholesterolemia, increased Lp(a) with its glycoxidative modification, as well as quantity and quality abnormalities of high-density lipoprotein with impaired collateral formation. We also analyzed the influence of innovative lipid-modifying strategies on coronary collateral development. Therefore, clinical management of diabetic dyslipidemia should take into account of its effect on coronary collateralization in patients with occlusive coronary artery disease.

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