A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury

Yi-Bing Chen; Ya-Bin Zhang; Yu-Le Wang; Prabhleen Kaur; Bo-Guang Yang; Yan Zhu; Lei Ye; Yuan-Lu Cui

doi:10.1186/s12951-022-01452-3

Journal of Nanobiotechnology (Jun 2022)

A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury

Yi-Bing Chen,
Ya-Bin Zhang,
Yu-Le Wang,
Prabhleen Kaur,
Bo-Guang Yang,
Yan Zhu,
Lei Ye,
Yuan-Lu Cui

Affiliations

Yi-Bing Chen: State Key Laboratory of Component-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine
Ya-Bin Zhang: Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan
Yu-Le Wang: Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, TEDA
Prabhleen Kaur: Department of Chemical Engineering, University of Washington
Bo-Guang Yang: Department of Biomedical Engineering, The Chinese University of Hong Kong
Yan Zhu: State Key Laboratory of Component-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine
Lei Ye: Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
Yuan-Lu Cui: State Key Laboratory of Component-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine

DOI: https://doi.org/10.1186/s12951-022-01452-3
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 17

Abstract

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Highlights Quercetin (QU)-Nanogel shows a significant therapeutic effect on acute lung injury. Quercetin as an active substance, was also involved in the nanogel construction. The novel nanogel increase the bioavailability of quercetin. Inhalation of QU-Nanogel allows the drug to reach the lungs directly.

Published in Journal of Nanobiotechnology

ISSN: 1477-3155 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Medicine: Medicine (General): Medical technology
Website: https://jnanobiotechnology.biomedcentral.com/

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Abstract

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