Olfactory dysfunction and the role of stem cells in the regeneration of olfactory neurons
Pengju Yu,
Weiguan Chen,
Ling Jiang,
Yufeng Jia,
Xiaoyan Xu,
Weiye Shen,
Ni Jin,
Hongjie Du
Affiliations
Pengju Yu
Department of Otolaryngology, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Weiguan Chen
Operating Room, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Ling Jiang
Operating Room, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Yufeng Jia
Operating Room, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Xiaoyan Xu
Operating Room, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Weiye Shen
Operating Room, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Ni Jin
Operating Room, Traditional Chinese Medicine Hospital of Kunshan, Jiangsu Province, China
Hongjie Du
Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, China; Corresponding author. Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, 250021, Jinan, Shandong Province, China.
The prevalence of COVID-19 has drawn increasing attention to olfactory dysfunction among researchers. Olfactory dysfunction manifests in various clinical types, influenced by numerous pathogenic factors. Despite this diversity, the underlying pathogenesis remains largely elusive, contributing to a lack of standardized treatment approaches. However, the potential regeneration of olfactory neurons within the nasal cavity presents a promising avenue for addressing olfactory dysfunction effectively. Our review aims to delve into the current research landscape and treatment modalities concerning olfactory dysfunction, emphasizing etiology, pathogenesis, clinical interventions, and the role of stem cells in regenerating olfactory nerves. Through this comprehensive examination, we aim to provide valuable insights into understanding the onset, progression, and treatment of olfactory dysfunction diseases.
