Multidimensional Analyses of Tumor Immune Microenvironment Reveal the Possible Rationality of Immunotherapy and Identify High Immunotherapy Response Subtypes for Renal Papillary Cell Carcinoma

Baojun Wei; Meng Yu; Meng Yu; Jihang Yao; Mingzhe Jiang; Jun An; Jieping Yang; Jiaxing Lin; Yongkang Zhao; Yongkang Zhao; Yuyan Zhu; Yuyan Zhu

doi:10.3389/fimmu.2021.657951

Frontiers in Immunology (Aug 2021)

Multidimensional Analyses of Tumor Immune Microenvironment Reveal the Possible Rationality of Immunotherapy and Identify High Immunotherapy Response Subtypes for Renal Papillary Cell Carcinoma

Baojun Wei,
Meng Yu,
Meng Yu,
Jihang Yao,
Mingzhe Jiang,
Jun An,
Jieping Yang,
Jiaxing Lin,
Yongkang Zhao,
Yongkang Zhao,
Yuyan Zhu,
Yuyan Zhu

Affiliations

Baojun Wei: Department of Urology, The First Hospital of China Medical University, Shenyang, China
Meng Yu: Department of Laboratory Animal Science, China Medical University, Shenyang, China
Meng Yu: Key Laboratory of Transgenic Animal Research, China Medical University, Shenyang, China
Jihang Yao: Department of Gynecology, The First Hospital of China Medical University, Shenyang, China
Mingzhe Jiang: Department of Urology, The First Hospital of China Medical University, Shenyang, China
Jun An: Department of Urology, The First Hospital of China Medical University, Shenyang, China
Jieping Yang: Department of Urology, The First Hospital of China Medical University, Shenyang, China
Jiaxing Lin: Department of Urology, The First Hospital of China Medical University, Shenyang, China
Yongkang Zhao: National Institute of Health and Medical Big Data, China Medical University, Shenyang, China
Yongkang Zhao: Joint Laboratory of Artificial Intelligence and Precision Medicine of China Medical University and Northeastern University, Northeastern University, Shenyang, China
Yuyan Zhu: Department of Urology, The First Hospital of China Medical University, Shenyang, China
Yuyan Zhu: Joint Laboratory of Artificial Intelligence and Precision Medicine of China Medical University and Northeastern University, Northeastern University, Shenyang, China

DOI: https://doi.org/10.3389/fimmu.2021.657951
Journal volume & issue: Vol. 12

Abstract

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Kidney renal papillary cell carcinoma (KIRP), the second most common subtype of renal cell carcinoma, still lacks effective treatment regimens for individualized immunotherapy because of the heterogeneity of its elusive immune microenvironment. Therefore, we aimed to comprehensively evaluate the immune microenvironment of KIRP by using the computational biology strategy to analyze the expression profile data of 289 KIRP patients obtained from The Cancer Genome Atlas database. Based on multidimensional, multi-omics bioinformatics analysis, we found that the tumor of patients with KIRP exhibited “hot” tumor characteristics but the CD8+ T cells in the tumor tissues did not limit tumor progression. Thus, patients with KIRP may realize higher clinical benefits by receiving treatment that can reverse CD8+ T-cell exhaustion. Among them, C1 and C3 immune subtypes could realize the best efficacy of reversing CD8+ T-cell exhaustion. Moreover, CCL5 and FASLG expression may be related to the formation of the immunosuppressive microenvironment in the tumors of patients with KIRP. In conclusion, the immune microenvironment landscape presented in this study provides a novel insight for further experimental and clinical exploration of tailored immunotherapy for patients with KIRP.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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