Nature Communications (Feb 2019)

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity

  • Yu Hui Kang,
  • Amlan Biswas,
  • Michael Field,
  • Scott B. Snapper

DOI
https://doi.org/10.1038/s41467-019-08743-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of experimental colitis via the adoptive transfer of CD4 T cells.