Primary biliary cholangitis complicated with eosinophilic granulomatous with polyangiitis: a case report

Abstract

The etiology of primary biliary cholangitis （PBC） is unclear， which may be associated with genetic， hereditary and environmental factors， etc. Ursodeoxycholic acid （UDCA） is the first-line drug for the treatment of PBC. Eosinophilic granulomatous with polyangiitis （EGPA） is a systemic vascular inflammatory disease characterized by necrotizing vasculitis， infiltration of eosinophils in tissues and organs， and formation of extravascular granulomas. In this report， a 65-year-old male patient presented with recurrent rashes on four limbs， recurrent abnormal liver function， asthma-like wheezing， microscopic hematuria， abnormal renal function， and eosinophilia. He was finally diagnosed with PBC complicated with EGPA. This case suggests that the possibility of rheumatic immune system disease should be considered for patients with unexplained eosinophilia complicated with multiple organ damage， such as skin， lung， liver， kidney， and immune system.

Keywords

• primary biliary cholangitis|cirrhosis of liver|eosinophilic granulomatous with polyangiitis|eosinophilia|multiple organ damage