Nature Communications (Jan 2019)

Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

  • Xiaohan Sun,
  • Yan Ding,
  • Meixiao Zhan,
  • Yan Li,
  • Dongqing Gao,
  • Guiping Wang,
  • Yang Gao,
  • Yong Li,
  • Shian Wu,
  • Ligong Lu,
  • Qingxin Liu,
  • Zizhang Zhou

DOI
https://doi.org/10.1038/s41467-019-08334-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.