Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques

Gregory A Engel; Alicia K Wilbur; Andrew Westmark; Dara Horn; Jordan Johnson; Lisa Jones-Engel

doi:10.1038/emi.2012.31

Emerging Microbes and Infections (Jul 2012)

Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques

Gregory A Engel,
Alicia K Wilbur,
Andrew Westmark,
Dara Horn,
Jordan Johnson,
Lisa Jones-Engel

Affiliations

Gregory A Engel: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington, Seattle 98125, WA, USA
Alicia K Wilbur: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington, Seattle 98125, WA, USA
Andrew Westmark: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington, Seattle 98125, WA, USA
Dara Horn: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington, Seattle 98125, WA, USA
Jordan Johnson: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington, Seattle 98125, WA, USA
Lisa Jones-Engel: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington, Seattle 98125, WA, USA

DOI: https://doi.org/10.1038/emi.2012.31
Journal volume & issue: Vol. 1, no. 1
pp. 1 – 5

Abstract

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Here we present a case series from a primate research facility. The index case, a 4-year-old pig-tailed macaque (Macaca nemestrina) experimentally infected with chimeric simian-human immunodeficiency virus (SHIV SF162 P4 ), developed weight loss and was euthanized. Based on necropsy results the animal was diagnosed with opportunistic atypical mycobacteriosis associated with simian AIDS (SAIDS). Subsequently, tissues from the index animal, as well as tissues and oral mucosal swabs from six SHIV-infected contacts, were analyzed using molecular methods and found to contain nucleic acid sequences characteristic of Mycobacterium tuberculosis complex (MTBC). These data suggest that existing protocols fail to reliably detect MTBC infection in laboratory primates used as experimental models.Emerging Microbes & Infections (2012) 1, e30; doi:10.1038/emi.2012.31

atypical mycobacteriosis; coinfection; IS6110; Macaca; MTBC; pig-tailed macaque; SHIV SF162 P4

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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