Nature Communications (Jul 2017)
Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
- Zhipeng Xu,
- Lei Xu,
- Wei Li,
- Xin Jin,
- Xian Song,
- Xiaojun Chen,
- Jifeng Zhu,
- Sha Zhou,
- Yong Li,
- Weiwei Zhang,
- Xiaoxiao Dong,
- Xiaowei Yang,
- Feng Liu,
- Hui Bai,
- Qi Chen,
- Chuan Su
Affiliations
- Zhipeng Xu
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Lei Xu
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Wei Li
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Xin Jin
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Xian Song
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Xiaojun Chen
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Jifeng Zhu
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Sha Zhou
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Yong Li
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Weiwei Zhang
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Xiaoxiao Dong
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Xiaowei Yang
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Feng Liu
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- Hui Bai
- Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University
- Qi Chen
- Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University
- Chuan Su
- Department of Pathogen Biology and Immunology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
- DOI
- https://doi.org/10.1038/ncomms16035
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 polarization and associated type 2 immune responses.
