Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation

Nabila Founounou; Reza Farhadifar; Giovanna M. Collu; Ursula Weber; Michael J. Shelley; Marek Mlodzik

doi:10.1038/s41467-021-27253-0

Nature Communications (Nov 2021)

Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation

Nabila Founounou,
Reza Farhadifar,
Giovanna M. Collu,
Ursula Weber,
Michael J. Shelley,
Marek Mlodzik

Affiliations

Nabila Founounou: Dept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
Reza Farhadifar: Center for Computational Biology, Flatiron Institute, Simons Foundation
Giovanna M. Collu: Dept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
Ursula Weber: Dept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
Michael J. Shelley: Center for Computational Biology, Flatiron Institute, Simons Foundation
Marek Mlodzik: Dept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-021-27253-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Ommatidial rotation in the Drosophila eye is a regulated process and a Planar Cell Polarity (PCP) cell motility model. Here, the authors show that tissue fluidity via junctional remodeling, as regulated by the PCP effector kinase Nemo, is critical for this cell motility process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal