Synthesis of metal–organic nanofiber/rGO nanocomposite as the sensing element for electrochemical determination of hypoxanthine

Abstract

In this study, metal–organic nanofibers (MONFs) and reduced graphite oxide (rGO) nanocomposite were used to modify the surface of glassy carbon electrode, and the electrochemical sensor was applied to the differential pulse voltammetry determination of hypoxanthine, the oxidation intermediate of human purine degradation metabolism. The preparation of MONFs/rGO nanocomposite is simple, efficient, and environmentally friendly. The morphology and structure of MONFs/rGO nanocomposite were characterized by field emission scanning electron microscopy and X-ray diffraction. The results show that the improved sensor has a significant increase in current density, with linear ranges of 0.1–10 and 20–100 μM. Detection limit 0.01 μM (S/N = 3). Under the optimized conditions, the improved sensor shows very good stability, selectivity, and improved accuracy.

Keywords

• metal–organic nanofibers
• rgo
• hypoxanthine detection
• electrochemical biosensor