Communications Biology (Jun 2021)
Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern
- Sébastien Tabariès,
- Matthew G. Annis,
- Anthoula Lazaris,
- Stephanie K. Petrillo,
- Jennifer Huxham,
- Amri Abdellatif,
- Vincent Palmieri,
- Jaclyn Chabot,
- Radia M. Johnson,
- Steven Van Laere,
- Cornelis Verhoef,
- Yasmina Hachem,
- Sara Yumeen,
- Nicholas Meti,
- Atilla Omeroglu,
- Gulbeyaz Altinel,
- Zu-Hua Gao,
- Alan S. L. Yu,
- Dirk J. Grünhagen,
- Peter Vermeulen,
- Peter Metrakos,
- Peter M. Siegel
Affiliations
- Sébastien Tabariès
- Goodman Cancer Research Centre, McGill University
- Matthew G. Annis
- Goodman Cancer Research Centre, McGill University
- Anthoula Lazaris
- Department of Surgery, McGill University Health Center
- Stephanie K. Petrillo
- Department of Surgery, McGill University Health Center
- Jennifer Huxham
- Goodman Cancer Research Centre, McGill University
- Amri Abdellatif
- Department of Surgery, McGill University Health Center
- Vincent Palmieri
- Department of Surgery, McGill University Health Center
- Jaclyn Chabot
- Department of Surgery, McGill University Health Center
- Radia M. Johnson
- Department of Bioinformatics & Computational Biology, Genentech Inc.
- Steven Van Laere
- University of Antwerp, Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
- Cornelis Verhoef
- Department of Surgical Oncology, Erasmus MC Cancer Institute
- Yasmina Hachem
- Goodman Cancer Research Centre, McGill University
- Sara Yumeen
- Goodman Cancer Research Centre, McGill University
- Nicholas Meti
- Goodman Cancer Research Centre, McGill University
- Atilla Omeroglu
- Department of Pathology, McGill University Health Center
- Gulbeyaz Altinel
- Department of Pathology, McGill University Health Center
- Zu-Hua Gao
- Department of Pathology, McGill University Health Center
- Alan S. L. Yu
- Jared Grantham Kidney Institute, University of Kansas Medical Center
- Dirk J. Grünhagen
- Department of Surgical Oncology, Erasmus MC Cancer Institute
- Peter Vermeulen
- University of Antwerp, Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
- Peter Metrakos
- Department of Surgery, McGill University Health Center
- Peter M. Siegel
- Goodman Cancer Research Centre, McGill University
- DOI
- https://doi.org/10.1038/s42003-021-02189-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Tabariès et al. describe that claudin 2 is a promoter of colorectal cancer liver metastasis. Furthermore, high Claudin-2 expression is associated with shorter time to liver-specific recurrence and is a biomarker of replacement type CRC liver metastases.
