Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Nathan Greiner; Beatrice Barra; Giuseppe Schiavone; Henri Lorach; Nicholas James; Sara Conti; Melanie Kaeser; Florian Fallegger; Simon Borgognon; Stéphanie Lacour; Jocelyne Bloch; Grégoire Courtine; Marco Capogrosso

doi:10.1038/s41467-020-20703-1

Nature Communications (Jan 2021)

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Nathan Greiner,
Beatrice Barra,
Giuseppe Schiavone,
Henri Lorach,
Nicholas James,
Sara Conti,
Melanie Kaeser,
Florian Fallegger,
Simon Borgognon,
Stéphanie Lacour,
Jocelyne Bloch,
Grégoire Courtine,
Marco Capogrosso

Affiliations

Nathan Greiner: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL)
Beatrice Barra: Department of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg
Giuseppe Schiavone: Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne
Henri Lorach: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL)
Nicholas James: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL)
Sara Conti: Department of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg
Melanie Kaeser: Department of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg
Florian Fallegger: Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne
Simon Borgognon: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL)
Stéphanie Lacour: Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne
Jocelyne Bloch: Defitech Center for Interventional Neurotherapies (NeuroRestore)
Grégoire Courtine: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL)
Marco Capogrosso: Department of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg

DOI: https://doi.org/10.1038/s41467-020-20703-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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The efficacy of epidural electrical stimulation (EES) to engage arm muscles and improve movement after spinal cord injury is still unclear. Here, the authors investigated how EES can recruit upper-limb motor neurons by combining computational modelling with experiments in non-human primates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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