Frontiers in Pharmacology (May 2021)

Impact of DAA Treatment on Cardiovascular Disease Risk in Chronic HCV Infection: An Update

  • Hrvoje Roguljic,
  • Hrvoje Roguljic,
  • Hrvoje Roguljic,
  • Vjera Nincevic,
  • Vjera Nincevic,
  • Kristina Bojanic,
  • Kristina Bojanic,
  • Kristina Bojanic,
  • Lucija Kuna,
  • Lucija Kuna,
  • Robert Smolic,
  • Robert Smolic,
  • Aleksandar Vcev,
  • Aleksandar Vcev,
  • Aleksandar Vcev,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Dragan Primorac,
  • Andrijana Vceva,
  • Andrijana Vceva,
  • George Y. Wu,
  • Martina Smolic,
  • Martina Smolic

DOI
https://doi.org/10.3389/fphar.2021.678546
Journal volume & issue
Vol. 12

Abstract

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Hepatitis C virus (HCV) infection is a systemic disease associated with multiple significant extrahepatic manifestations. Emerging studies indicate association between the HCV infection and a higher incidence of major adverse cardiovascular events such as: coronary artery disease, heart failure, stroke and peripheral artery disease, when compared to general population. Atherosclerosis is a common pathophysiologic mechanism of cardiovascular disease (CVD) development which is the leading cause of mortality in the Western world. Proposed mechanisms of HCV-induced atherosclerosis includes systemic inflammation due to the chronic infection with increased levels of pro-atherogenic cytokines and chemokines. Furthermore, it has been demonstrated that HCV exists and replicates within atheroschlerotic plaques, supporting the theory of direct pro-atherogenic effect of the virus. Direct acting antiviral agents (DAAs) represent a safe and highly effective treatment of HCV infection. Beside the improvement in liver-related outcomes, DAAs exhibit a beneficial effect on extra-hepatic manifestations of chronic HCV infection. Recently, it has been shown that patients with chronic HCV infection treated with DAA-based therapeutic regimes had a 43% reduction of CVD events incidence risk. Moreover, eradication of HCV with DAAs results in a significant positive effect on risk factors for cardiovascular disease, despite a general worsening of the lipid profile. This positive effects is mainly due to an improvement of endothelial function and glucose metabolism. Although DAA treatment is associated with a beneficial impact on cardiovascular events, further studies are needed to fully elucidate the mechanisms responsible.

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